MTT assay was used to determine the in vitro cytotoxicity. A metastatic ACC (ACC-M) cell line and control cells (MRC-5 cells derived from normal lung tissue) were treated with APs at different concentrations. We aimed to evaluate the effect of apple polyphenols (APs), a novel nutraceutical agent, on the proliferation and apoptosis levels in a metastatic oral ACC cell line. Conventional chemotherapy for ACC produces a poor result. An independent body of specialists later recommended theĪdenoid cystic carcinoma (ACC) is characterized by intensive local invasion and high incidence of distant metastases. This was particularly important after the 1859 Smethurst case, in which a leading toxicologist had been forced to admit that his earlier findings of arsenic in the tissues of a dead woman – which had led to the verdict that Thomas Smethurst was guilty of murder by poisoning – had been mistaken. Rather than inventing forensic science, the Holmes stories instead presented the ‘science of criminal detection’ in a positive light in Britain. he old guaiacum test was very clumsy and Conclusion Don't you see that it gives us an infallible test for blood stains?…. t is the most practical medico-legal discovery for years. ‘I have found a re-agent which is precipitated by haemoglobin, and by nothing else…. I've found it! I've found it,’ he shouted to my companion, running towards us with a test-tube in his hand. In A Study in Scarlet, Dr Watson first meets Holmes in a laboratory, where Holmes has been experimenting on bloodstains. ![]() ![]() Conan Doyle explicitly signals his appropriation of Bacon's method by having Holmes remark in A Study in Scarlet that the detective must reason as he does in order to ‘interpret Nature’, a phrase famously used by Bacon in defining his own Holmes: the ‘father of scientific criminal detection’? These rules reflect common images of the work of Francis Bacon, the 17th-century philosopher of science whose writings became extremely popular in 19th-century Britain. Holmes also describes various ‘rules of deduction’ that he uses in reasoning backwards. More recently, the comparative anatomist Richard Owen (Figure 2) had Rules to ‘interpret Nature’ Huxley lauded the skill of Georges Cuvier, who had been able to reconstruct ‘entire animals from a tooth or perhaps a fragment of bone’. In one of his popular lectures on science, Thomas H. Holmes' description of his method of reasoning is similar to that used in the ‘historical’ or ‘palaetiological’ sciences of paleontology, archeology and geology, which by that time had captured the imagination of the literate public. ![]() Section snippets Holmes and the historical sciences
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